Deorro began his DJ career by playing at local gigs when he was 14. He was born in Los Angeles to Mexican parents. By the time Deorro turned 17, he was already producing his own tracks. In 2012, he was asked by DJ Chuckie to remix his track "Make Some Noise". Deorro's remix landed in the top 50 on Beatport. He has since remixed tracks from multiple international famed DJs such as Steve Aoki, Laidback Luke, and Gareth Emery, among others.
In 2013, he released the track "Yee" on Hardwell's label, Revealed Recordings, which in Austria, Belgium, France, Germany, Netherlands, and Switzerland. On 18 March 2014 he released the single "Freak" with Steve Aoki and Diplo. On 24 March 2014 he released the single "Flashlight" with R3hab. He released the single "Five Hours" in April 2014. The track charted in Austria, Belgium, France, Netherlands, Norway, Sweden and Switzerland. On 17 May 2014, Deorro announced on his Twitter page he was going to take a break from DJing in order to have a bigger focus in making music and expanding his record label, PandaFunk. In August 2014 he released the single "Rambo" with J-Trick. On 18 October 2014, Deorro received the award for highest new entry on the 'DJmag top 100 DJs 2014' contest, he hit spot 19. He also played a half hour set at the 'DJmag top 100 DJs' event, which took place during ADE in Amsterdam, the Netherlands. In December 2014 he released the single "Perdoname". In March 2015 he released a third version of "Five Hours" with Chris Brown titled "Five More Hours", the song has charted in Ireland, Netherlands and Sweden.