Gisselle was born in New York to Puerto Rican parents. She showed interest in the arts from an early age and started dancing at the Ita Medina Academy when she was 15 years old. She participated as a dancer in several shows in venues like the Luis A. Ferré Performing Arts Center. After that she became a regular dancer and performer in variety shows like Super Sábados and El Show de las 12.
It was then that she started to incline towards a career in music. She joined Kaviar, a merengue group composed of females, with whom she performed for almost two years. From 1991 to 1993, she performed with the group Punto G. After that, she decided to pursue a solo career and was signed by the BMG label.
In 1995, Bonny Cepeda produced her first album that produced several hit singles like "Perfume de mujer en tu camisa" and "Pesadilla". It was also awarded gold and platinum albums, and several awards.
In 1996, her second album - A Que Vuelve - was released to much praise. The album reached 200,000 units sold. Her third album, Quiero Estar Contigo, was equally successful reaching the top places in the Billboard charts. The album featured a version of Juan Gabriel's song "Perdóname, olvídalo" in a duet with Dominican Sergio Vargas which was very successful. Upon this, they released an album together titled Juntos.
In the late 90s, Gisselle released the album Atada which garnered her a Grammy nomination. Her follow-up, Voy a Enamorarte, released in 2000, featured Gisselle singing ballads and bachatas. In 2002, she received another Grammy nomination for her album titled simply 8.
Gisselle's next album, En alma, cuerpo y corazón, featured the singer venturing into pop music. However, in 2004 she returned to merengue with her new album Contra la Marea.