Marcus Hopson was born on July 18, 1985 in Los Angeles, and was raised in the Panorama City neighborhood of Los Angeles. He attended James Monroe High School, where he was placed into special educational classes. Hopsin has been an avid skateboarder since the age of twelve, as many of his music videos feature him skateboarding. He started rapping at sixteen years old, and took his hobby more seriously by 2003 which is the year the majority of the tracks from Hopsin's self-produced album Emurge were recorded. He dropped out of high school during his senior year in 2004 to pursue a career in music, purchased a microphone, and installed FL Studio (known as FruityLoops at the time) on his computer. While starting his music career, Hopsin decided to sport colored eye contacts while performing in his music videos. He stated that he used the contacts to give himself a memorable appearance and differentiate himself from other African American rappers with the cliché appearance. He credits Eminem as the rapper that initially got him interested into hip hop music.
On July 1, 2014, Hopsin posted a picture of his mugshot stating that he would be releasing "Ill Mind of Hopsin 7" on July 18, 2014. He then stated that it was for sure the realest song he has ever wrote in his career.The video for "Ill Mind of Hopsin 7" had gotten over 1 million YouTube views in a day. On "Ill Mind of Hopsin 7", Hopsin lyrically shares his religious beliefs, his views on other religious beliefs and the connections between religion, history and governance.
Hopsin had revealed on his instagram that he'd be retiring from rap and moving to Australia. However on December 25, 2014, Hopsin shared a video on his YouTube channel called "The REAL reason Hopsin left the music industry" with label mate Jarren Benton inspired by the film Dumb and Dumber To which stated that he was not quitting rap and it was all a joke, also revealing that he will be releasing a new album called Pound Syndrome in 2015.
On May 27, 2015, an interview was released on Sway Calloway's YouTube channel, touching on his appearance at Soundest Music Festival, and announcing that Pound Syndrome would be released on July 24. In the interview, he said that this is "definitely the best album that [he's] ever created, hands down."