Juvenile first began recording his raps in the early 1990s. One of his early recordings was featured on DJ Jimi's 1991 release, "It's Jimi". The song "Bounce For the Juvenile" was a minor local hit and helped popularize "bounce music," a new rap style emerging out of New Orleans.
Juvenile's debut album, Being Myself, was released in 1995 after signing with Warlock Records. The album did not gain much national attention and did not chart, but did fairly well on a local level.
After the regional success of his debut Juvenile signed to the larger Cash Money Records. In 1997 Solja Rags, Juvenile's debut album with Cash Money Records, was released. It became popular among local rap audiences, and also saw some national success as it charted on the Billboard Hot R&B/Hip-Hop Songs chart. It was the first time he worked with Cash Money in-house producer Mannie Fresh, who would go on to produce all of Juvenile's albums on Cash Money in their entirety except Juve the Great. Also in 1997, Juvenile joined the Hot Boys with fellow Cash Money rappers B.G., Turk, and Lil Wayne. They released their debut album as a group, titled Get It How U Live!.
Juvenile's next album, titled 400 Degreez, was released in 1998. It was his breakout to the national rap scene. The Cash Money label now had joint distribution by Universal Records, which gave the music much more national promotion. This along with much more critically praised music made Juvenile a mainstream star. The album's first single "Ha" and later "Back That Azz Up" both became very successful songs charting on the Billboard Hot 100 and the Hot R&B/Hip-Hop Songs chart. Powered by these two singles, 400 Degreez was eventually certified 4X platinum by the RIAA. It is his best selling album to date. However, there came a dispute over who owned the rights to the title of "Back That Azz Up", as another New Orleans performer DJ Jubilee claimed that Juvenile's song sounded very similar to a song of his. In January 2005, the United States Court of Appeals for the Fifth Circuit in New Orleans denied the case.
In 1998, capitalizing off Juvenile's popularity off 400 Degreez, a remixed version of Being Myself and reissue of Solja Rags were released. The second Hot Boys group album, Guerrilla Warfare also came out and was successful, being certified Platinum. Over the next few years Juvenile released two more solo albums for Cash Money: Tha G-Code in 1999 being certified Double Platinum, and Project English in 2001 being certified Platinum. These albums each were very successful as they both reached the top 10 of the Billboard Hot 200, but they did not match the success of 400 Degreez. UTP Records had promised an album titled 600 Degreez but it never materialized.
Juvenile's manager Aubrey Francis and Cash Money's Baby met and worked out a deal for Juve and CMR to partner for another album. Juvenile returned to Cash Money Records in 2003, releasing Juve the Great. Juve The Great was certified Platinum; it featured the number-one hit "Slow Motion" featuring Soulja Slim. It was the only number-one hit for Juvenile and Slim before Slim died in November 2003. The last Hot Boys album Let 'Em Burn came out in 2003.
In 2005 Juvenile signed a new deal with Atlantic Records for himself, and also a separate label deal for his UTP Records imprint. UTP Records is the label that was started by Juve along with his longtime manager Aubrey "Pied Piper" Francis, and older brother Corey. The group called "UTP" (Juve, Skip, and Wacko) released the hit song "Nolia Clap" as part of UTP Records first album release. It was produced by Juve along with producer XL Robertson. Atlantic Records. Juvenile also performed the song "Booty Language". It was part of the soundtrack for the movie Hustle And Flow. Juve performed alongside fellow Atlantic artist at the movies premier party in West Hollywood, California. Juvenile's Slidell, Louisiana home was damaged during Hurricane Katrina. Juvenile and fellow New Orleans rapper Master P and other hip hop artists raised funds and supplies for some hurricane victims. He moved to Atlanta briefly after Hurricane Katrina in 2005. In Spring 2006 he returned home to New Orleans.
Reality Check, Juvenile's 2006 album, debuted at number one on the Billboard 200 chart, being his first number-one album. It was certified Gold. Production began in May 2005, most of it being done at a Holiday Inn hotel room in New Orleans. Its first single was "Animal", followed by "Rodeo", "Get Ya Hustle On" produced by Donald XL Robertson, "What's Happenin'" Produced by Terrence "Sinista" Freeman, and "Way I Be Leanin'" featuring Mike Jones, Paul Wall, Skip, and Wacko. A portion of the album was recorded with engineer, Stewart Cararas at his studio Paradigm Park Studios in New Orleans. Within one month, the studio suffered the wrath of Hurricane Katrina. Stewart now lives and operates in Los Angeles. On signing to Atlantic, Juvenile criticized his former label Cash Money for not giving him enough creative freedoms as well as Federal Emergency Management Agency over his perceptions over their handling of Hurricane Katrina. Shaheem Reid noted "Get Ya Hustle On" as a criticism of Ray Nagin's and the George W. Bush administration's handling of the whole Hurricane Katrina Disaster.
In a 2009 interview with Allhiphop.com writer Han O'Connor, Juvenile stated that his album Cocky & Confident would take a totally different direction from his last project, which was made when he was still "mourning Katrina." He also revealed that he decided to work only with fresh, young producers on the album and discussed his respect for younger artists like Soulja Boy.
Cocky & Confident was released in December 2009. It peaked at #49 on the Billboard 200. It was Juvenile's lowest charting album since 1997. It featured one charting single, "Gotta Get It", which peaked at #53 on the Billboard R&B/Hip-Hop Singles chart. Following this album's release Juvenile began work on his next album, Beast Mode. This album was released in July 2010. Its first single is titled "Drop That Thang".
Juvenile released his tenth studio album Rejuvenation on June 19, 2012, which was distributed by Rap-A-Lot Records. The first single from the album is "Power" featuring Rick Ross. Juvenile collaborated with Lil Wayne, DJ Khaled, and Drake for the album. On October 28, 2014 Juvenile announced that he re-signed to Cash Money.