While the show mainly focuses on themselves and comedy, the show occasionally features vocal performances by Grassi and Hoying. They also tend to have a number of collaborations with many YouTube celebrities, such as Tyler Oakley, Hannah Hart, Mamrie Hart, Miranda Sings, Todrick Hall, Ricky Dillon, and Connor Franta.
On October 18, 2016, the pair released an original song, "Bad 4 Us", on their channel. Later, on November 15, 2016, they released a second original song, "Sweet Life", with more official music planned for 2017.
As of May 2017, the channel has over two million subscribers and has accumulated over 310 million views.
On June 30, Superfruit released an EP titled Future Friends: Part One. The EP consists of songs about the duo's relationship such as "Worth It (Perfect)", "Future Friends", "Vacation", and "Bad 4 Us". Superfruit plans to release part two of Future Friends on September 15.
According to Grassi, he and Hoying were at IHOP one day and both discussed how they wanted to individually start YouTube channels. They decided to launch one together. According to Hoying, the name Superfruit "came from Mitch's random mind". The first Superfruit video was released on August 13, 2013.
Superfruit consists mainly of vlogs about the duo's daily lives and various casual games and competitions, but the channel also features a number of musical projects. Both Grassi and Hoying are members of the LGBTQ community. Although they are not dating anymore, the pair gave themselves the portmanteau Scömìche to represent their relationship. Together they have a cat named Wyatt Blue Grassi-Hoying, who appears in a number of their videos and logo. Most videos feature just Hoying and Grassi, however several include other artists or guests.
Superfruit has had many different end segments to their videos, which have varied over time but (as of September 2015) consist of Song Suggestions and Weekly Obsessions. The 'Weekly Obsessions' segment began from the first Superfruit episode and has continued ever since. They usually consist of items that Grassi or Hoying have recently purchased, and are often items of clothing. In the 'Comment on Comments' segment, inspired by YouTuber Grace Helbig's previous channel, DailyGrace, featured a number of comments on the last week's video, which were commented on by Grassi and Hoying. It featured one positive and one negative comment. This segment was discontinued after the episode "HEADS UP!". In the eighth episode of their web show, Superfruit began making weekly song suggestions. They entitled this segment 'Hey everyone! Here's a good song! *Don't listen to anything else today', which has adapted through each episode.
Outside of their YouTube channel, Grassi and Hoying promoted The SpongeBob Movie: Sponge Out of Water as Superfruit with an MTV commercial in which Grassi gets a tattoo of SpongeBob on his arm.
As Superfruit, Grassi and Hoying appeared on The Grace Helbig Show.
As of 2017, Grassi and Hoying have also begun featuring on other artists original songs; they feature on Betty Who's "Beautiful" from her second studio album The Valley, credited as 'Superfruit'. Additionally, Grassi and Hoying featured with fellow Pentatonix member Kirstin Maldonado in Todrick Hall's "Black and White" from the deluxe edition of Straight Outta Oz, with all three featuring artists collectively being credited as 'Superfruit'.