In April 2008 the band, composed of members Sean Foreman and Nathaniel Motte, signed with Photo Finish Records (a subsidiary of Atlantic Records). Foreman and Motte met in a physics class at the University of Colorado. The members were inspired by the underground hip-hop scene and Foreman, then a member of the band Eight Hour Orphans, invited Motte to mix some beats with him. The two were helped early on by friendships they had made with local acts such as Grace Gale, Signal to Noise and The Blackout Pact. As Motte puts it, "We had it pretty easy. We had a lot of friends in bands who chaperoned us around and got us shows, and that was enough hype or buzz to get us going on our own."
The band has gained street cred by, among other things, opening for Snoop Dogg several times. After playing the Denver leg of Warped Tour in 2007, 3OH!3 has signed on for all venues of Warped Tour 2008 and their song "PunkBitch" is on the Warped Tour 2008 Tour Compilation. The band has also played at national festivals such as Bamboozle Left and the Pemberton Festival in British Columbia. 3OH!3 commonly uses skits and costumes during their live concerts.
3OH!3's debut on Photo Finish Records, Want, was released on July 8, 2008.