Twista released his debut album Runnin' Off at da Mouth in 1991. At that time, he performed under the name Tung Twista.
In 1996, he teamed with fellow Chicago act Do or Die on the track "Po' Pimp", which became a hit single. This led to a contract with Atlantic Records, which released Adrenaline Rush in 1997. Twista had by then dropped the "Tung" from his stage name.
This was followed by Mobstability in 1998. Twista then formed his own Legit Ballin' label, which released two compilation albums: Legit Ballin' in 1999 and Legit Ballin' Vol. 2: Street Scriptures in 2001. The label later released Respect The Game, Vol. 3 in 2002 and Volume 4: Tha Truth in 2006. In 2000, Twista collaborated with Ruff Ryders and Drag-On on the Ruff Ryders: Ryde or Die Vol. 2 album, on the track "Twisted Heat."
Beginning in 2002, Twista began recording his album Kamikaze with rappers like Jay-Z and Ludacris. Kamikaze came out in 2004 and debuted at the top spot of the American Billboard 200 album chart at #1. Its first single "Slow Jamz" (also featured on Kanye West's debut album The College Dropout), featured West and Jamie Foxx and became a number-one hit in the US. Other singles included "Overnight Celebrity" and "So Sexy" (featuring R. Kelly); the album sold around two million copies. The remix of the song "Jook Gal" by Elephant Man featured Twista and the YoungBloodZ.
Twista's next album, The Day After was released in 2005. It featured the hit singles "Girl Tonite" featuring Trey Songz, "Hit the Floor" featuring Pitbull, and "So Lonely (Twista song)" featuring Mariah Carey.
His next album, Adrenaline Rush 2007 came out in 2007. Its singles were "Give it Up" featuring Pharrell and "Creep Fast" featuring T-Pain. This album sold poorly compared to Twista's earlier albums.
Twista also appeared on the single "Hell No (Leave Home)" from Monica's album fall 2006 The Makings of Me.
In 2008, Twista launched a new record label, Get Money Gang Entertainment.
Twista has now released his sixth solo album called Category F5. According to Twista's myspace he has worked with producers such as The Legendary Traxster, The Tastemakers (Chad Beatz & Michaela Shiloh) and Jim Jonsin, and artists such as Tech N9ne, Busta Rhymes, and Young Jeezy.